Process of making guanin.



UNITED STATES PATENT OFFICE.

I LEO WEBER, OF DARMSTADT, GERMANY.

PROCESS OF MAKING GUANIN.

Specification of Letters Patent.

Patented Sept. 19, 1905.

Application filed July 6, 1905. Serial No. 268.548.

To all whom it may concern.-

Be it known that I, LEO WEBER, doctor of philosophy, and a subject ofthe Grand Duke of Baden, in the Empire of Germany, residing atDarmstadt, Germany, have invented a certain new and useful Improvementin the Production ofGuanin, of which the following is a specification.

In my application, Serial N 0. 223,746, filed September 8, 1904, I havedescribed a process for the obtainment of 2-cyanamido-4-amido-6-oxypyrimidin. It has been discovered that from this product by actionof nitrous acid 'and subsequent reduction in an acid or alkaacid salt ofthe base crystallizing out at the beginning soon goes into solution, andupon cooling the mass stifiens to a crystalline paste, which consists ofguanin formate. The crystals are separated from the mother-liquor andthe-substance is purified by repeatedly dissolving it in a hot solutionof sodium hydrate and precipitating it with acetic acid at boiling heat.The product thus obtained possesses all the properties of guanin, andits formation may theoretically be represented by the equation /CH.HNON// Iclaim The process of producing guanin by heating2-cyanamido-4-5-diamido-G-oxypyrimidin with formic acid.

LEO WEBER. Witnesses: MATHILDE WEBER, WALTER HOUSING.

